The Sequencing Conundrum
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The Sequencing Conundrum When I was first presented with the “sequencing conundrum,” I felt like I was in a horror movie. The first two steps of DNA replication were separated into separate molecules: the DNA template strand replicates the complementary strand and the strand replicates a short “g” fragment and a short “a” fragment, with a barcode sequence. But then, in the second step, “DNA polymerase polymerizes the complementary strand.” The problem is that DNA polymerase can polym
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The Sequencing Conundrum — an unsolved conundrum in the world of genomics This case study examines the challenges of sequencing genomes for clinical diagnosis, which has been an area of intense focus for the last several years. For example, the Human Genome Project (1990-2003) sequenced the genomes of 25 species of animals, plants and microbes (DNA and RNA). However, despite this unprecedented genome data, most patients diagnosed with cancer are
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I had always been an enthusiastic fan of the great composer, Mozart’s music. It was like I was connected to his soul. learn the facts here now He was such an amazing composer, creating complex works, taking risks, and never once afraid of risking anything. He was the greatest composer of his time. I got a chance to study his famous opera, The Magic Flute. My heart raced when I saw it for the first time. I loved everything about it – the music, the libretto, the sets, the costumes – it was simply amaz
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The Sequencing Conundrum: The World’s Most Complex Problem The sequencing conundrum is a complex problem affecting the world’s most complex problems, in which time and quality are often conflicting and the best results often depend on trade-offs. This is the ultimate quandary that plagues the modern world of businesses and entrepreneurs, where they must choose between quality and cost or between speed and quality. Problem Definition The sequencing conundrum refers to the complexity of assigning tasks or tasks to resources for
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We are currently working on a case study for an esteemed multinational corporation. The company has a plethora of data and records to go through before the report is submitted. The task was daunting because we had to sequence the data from each department, such as procurement, logistics, and manufacturing, and integrate them. To make things more challenging, the corporation has a hierarchical organization, which means that there are multiple levels to the hierarchy. The report needs to be written for multiple stakehold
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I am an ex-marketing executive and the author of this marketing plan (2020). Here, I explain The Sequencing Conundrum in my own words and share my experience, and I don’t claim that I know everything (no offense intended). One of the biggest struggles I faced during my 25 years as a marketer was trying to figure out where I should start with my marketing plan. Should I introduce the product, explain how it works, and provide benefits? Or should I first emphasize how the benefits can change
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Sequence is one of the most powerful tools in a scientist’s arsenal. Whether you’re dealing with a complex protein, a protein-protein complex or a DNA molecule, there’s a good chance that sequence can unlock important mysteries about a variety of biological functions. The problem is that sequences often don’t come to us out of the blue. Scientists have to work through a complex sequence-finding process to find their way to a particular protein that is going to do something interesting. Sequence analysis is expensive
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I had the privilege of working on a research project that involved sequencing 2000 genomes of five diverse human populations in collaboration with 15 scientists from 5 institutions. We were able to extract insights into gene expression across the broad spectrum of genes and their functional roles, using state-of-the-art sequencing technologies such as deep sequencing and Illumina HiSeq. This project was funded by DARPA, a US Department of Defense, as part of its effort to advance sequencing technology for personalized healthcare.